• Pluripotent stem cell marker analysis iPSCOCT express plurip

  2018-11-08

  

  Pluripotent stem cell marker analysis: iPSCOCT4 express pluripotent markers SSEA3, TRA-1-60, OCT4, NANOG and SOX2 as measured by flow cytometry (Fig. 1E). Pluripotent functionality: iPSCOCT4 are capable of three germ layer differentiation capacity as assessed by in vivo teratoma assay (Fig. 1F).

• br Materials and methods br Author disclosure

  2018-11-08

  

  Materials and methods Author disclosure statement Acknowledgments This work was supported by the UK Medical Research Council grants G0701172 and G0801061. We thank Dr. Yacoub Khalaf, Director of the Assisted Conception Unit of Guy\'s and St Thomas\' NHS Foundation Trust and his staff for su

• br Conclusions Seven days of induction to adipogenic

  2018-11-08

  

  Conclusions Seven days of induction to adipogenic differentiation promotes a transition from glycolytic metabolism to OXPHOS. During this period, induced motilin receptor showed an increment in oxygen consumption, suggesting a stimulus for oxidative phosphorylation in these cells. The NPT concen

• The most significant finding in these studies was

  2018-11-08

  

  The most significant finding in these studies was the 10-fold enhanced expansion of transplantable HSCs in mice engrafted with IK6-transduced human CD34+ CB cells. This was indicated both by the higher numbers of CD34+CD38− ubiquitin activating enzyme regenerated from the IK6-transduced cells after

• No effective therapies are available for motor neuron diseas

  2018-11-08

  

  No effective therapies are available for motor neuron diseases, including SMARD1. Neural stem cell (NSC) transplantation represents a possible therapeutic strategy for ameliorating the neurological phenotype by multiple mechanisms, including neuroprotection and cell replacement of different CNS cycl

• Previously our group has isolated human embryonic stem cells

  2018-11-08

  

  Previously, our group has isolated human embryonic stem calcium calmodulin dependent protein kinase (ESCs) whose pluripotent state is maintained in vitro by exogenous growth factor signaling, particularly fibroblast growth factor (FGF), insulin or insulin-like growth factor, and transforming growth

• br Future perspectives Human fetal tissue research and

  2018-11-08

  

  Future perspectives Human fetal tissue research and non human primate macaque models have been essential to the establishment of human PGCLC differentiation models to study mechanisms that contribute to early PGC allocation in the embryo. Together, these approaches have revealed that humans have

• br Materials and Methods br Results br Discussion The

  2018-11-08

  

  Materials and Methods Results Discussion The importance of bone marrow microenvironment in leukemogenesis becomes more evident each day. Kim and colleagues described the ability of leukemic stem pmsf to reset the communication between hematopoietic stem cells and the bone marrow microenvir

• Using expression data from teratomas we

  2018-11-08

  

  Using expression data from teratomas, we were able to identify a large variety of differentiated tissues within them. This allowed us to analyze a repertoire of differentiated cell types in each embryonic germ layer. Teratomas initiated from PSCs express characteristic genes of all analyzed tissues

• herpes simplex virus 2 ESC CMs can be subdivided into

  2018-11-08

  

  ESC-CMs can be subdivided into atrial and ventricular CMs (Burridge et al., 2012). It has been documented that the expression of the α-isoform of myosin heavy chain (α-MHC), MLC2a, and MLC1a become restricted to the atrium during murine development (Zammit et al., 2000). Here, we employed MLC2a and

• br Introduction Bone marrow derived mesenchymal stromal cell

  2018-11-08

  

  Introduction Bone marrow-derived mesenchymal stromal cell (BM-MSC)-derived osteoblasts and chondrocytes are responsible for bone and cartilage modeling/remodeling, respectively (Harada and Rodan, 2003; Wu et al., 2009). Osteoblasts are defined by lineage-specific transcription factors RUNX2 and O

• Taken together these findings indicate that basal to luminal

  2018-11-08

  

  Taken together, these findings indicate that basal-to-luminal differentiation can occur in prostate organogenesis, pathogenesis, and ex vivo assays, but rarely during normal tissue homeostasis. Thus, it has been unclear to what extent the plasticity of endogenous adult prostate basal glucocorticoid

• br Results br Discussion The Wnt signaling pathway has

  2018-11-08

  

  Results Discussion The Wnt signaling pathway has emerged as the dominant self-renewal pathway for various adult-type stem cells and is required for maintenance of embryonic as well as induced pluripotent stem cells. In the hematopoietic system, only mild increased Wnt dosages result in higher

• Although RA is sufficient to promote the

  2018-11-08

  

  Although RA is sufficient to promote the development of spermatogenic buy Biotin-tyramide from mSSCs to spermatocytes, the Sertoli cell co-culture increases further the induction efficiency. Severe apoptosis of the germ cells were observed under both the feeder-free and the co-culture conditions, i

• Active cell proliferation is key for transcription factor in

  2018-11-07

  

  Active cell proliferation is key for transcription factor-induced cell-fate change during cellular reprogramming. Because acute leukemias barely or do not proliferate in vitro, we endeavored to reprogram leukemic B cell lines as well as MLL-rearranged primary blasts induced to proliferate through xe

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