• We next compared the enhancing

  2022-08-18

  

  We next compared the enhancing effects of 100nM zinc on currents produced by a low concentration of glycine with zinc effects on the same currents produced by the partial agonist taurine. In this experiment, zinc was co-applied with concentrations of glycine or taurine producing 5–10% of the maximal

• br Declaration of interest br Acknowledgments br This

  2022-08-18

  

  Declaration of interest Acknowledgments This work was supported by grants from the Polish National Science Centre (PRELUDIUM grant no. 2013/11/N/NZ5/00270) and the European Commission FP7 Project Beta-JUDO (grant number 279 153), European Union EIT Health project DeTecT2D, Swedish Diabetes A

• Peripheral injury or disease induced alterations in synaptic

  2022-08-18

  

  Peripheral injury- or disease-induced alterations in synaptic efficacy occur not only at the first synapse made by the primary nociceptive afferents in the spinal dorsal horn but are also operational in several regions processing the sensorimotor as well as emotional-affective components of pain, su

• In Solloway and colleagues reported that mice with alpha cel

  2022-08-18

  

  In 2015, Solloway and colleagues reported that mice with alpha cell hyperplasia due to inactive hepatic glucagon receptor signaling may most likely be caused by amino hygromycin b dependent mechanisms [11]. The authors then showed these adaptations are regulated by ‘mechanistic target of rapamycin’

• In a mouse model of hyperhomocysteinemia

  2022-08-18

  

  In a mouse model of hyperhomocysteinemia (a risk factor for the development of vascular dysfunction) it has been shown that myoendothelial communication is enhanced due to increased expression of Cx37 and IK1 Nemadectin [], allowing the propagation of endothelial signals to VSMC and thereby decreas

• br Introduction Alzheimer s disease AD affects ca

  2022-08-18

  

  Introduction Alzheimer's disease (AD) affects ca. 46 million people worldwide [1] and it is expected that the number will double or triple by 2030 or 2050, respectively, while no significant progress has been made in research for early diagnosis and new efficient therapies. Currently available me

• At the end of experiments rats were injected

  2022-08-18

  

  At the end of experiments rats were injected high dose of sodium pentobarbital (90mg/kg) and the rat’s head was cut and frozen in −20°C for 20min with the injecting tube in situ before section. The location of the tip of the injecting tube was verified and all the tips of the injecting tube were in

• Homeobox genes can promote oncogenesis through multiple mech

  2022-08-18

  

  Homeobox genes can promote oncogenesis through multiple mechanisms, including gene translocation, loss of heterozygosity, gene amplification, DNA methylation, 20b remodeling, etc. For instance, translocation-mediated fusion of HOXA9 or HOXA13 on chromosome 7p15 with the nucleoporin gene NUP98 on chr

• FPR ligands comprise structurally very

  2022-08-18

  

  FPR ligands comprise structurally very diverse Immunology Compound Library of compounds, ranging from naturally occurring peptides/proteins or “danger signals” such as PAMPs and DAMPs (see 1.1), respectively, to endogenous lipids and even various synthetic non-peptides, such as benzimidazoles, pyra

• emca receptor So what makes a FFAR

  2022-08-18

  

  So what makes a FFAR1 agonist different and interesting? As shown in the , the cellular mechanism is different from those of present insulin-releasing pharmacotherapies—namely the secretion initiators (sulphonylureas and meglitinides) and the incretin-based secretion potentiators (glucagon-like pept

• According to the World Health

  2022-08-18

  

  According to the World Health Organization (WHO) classification, oligodendrogliomas or anaplastic oligodendrogliomas are primary neoplasms of the central nervous system, which are predominantly composed of cells morphologically resembling oligodendrocytes [23]. These tumors are often estimated to re

• On the other hand imidazolylcyclopropane derivatives and hav

  2022-08-17

  

  On the other hand, imidazolylcyclopropane derivatives and having a 2-substituted benzimidazolyl group showed moderate binding affinities for both the HR and HR. Replacement of 4-chlororbenzylamino group of with a benzimidazolyl group () led to increase the affinity for the HR more than 5-fold ( =

• Our data indicate that curcumin reduced

  2022-08-17

  

  Our data indicate that curcumin reduced MDA and LOOH formation in plasma and kidney induced by gentamicin treatment. The results demonstrate the protective effect of this compound against oxidative damage to these membranes. Moreover, the ability of curcumin to reduce the formation of LOOH induced b

• br Materials and methods br Results

  2022-08-17

  

  Materials and methods Results Discussion GSK-3 overexpression diminishes neurogenesis (Fuster-Matanzo et al., 2013, Kondratiuk et al., 2013, Sirerol-Piquer et al., 2011), while the inhibition of GSK-3 with lithium or valproate enhances neurogenesis, as measured by cell proliferation, the nu

• Two genes PATL and RASSF whose relationship to

  2022-08-17

  

  Two genes (PATL2 and RASSF1), whose relationship to HIV infection had not previously been reported, were identified in this study. Although PATL2 and RASSF1 have been implicated in cell division and tumor suppression, respectively (Scheller et al., 2007, Rather et al., 2014, Liu et al., 2002), their

16100 records 399/1074 page Previous Next First page 上5页 396397398399400 下5页 Last page