• br What are GMOs and

  2018-11-12

  

  What are GMOs and GM foods? Genetic modification is a biological technique that effects alterations in the genetic machinery of all kinds of living organisms. GMO is defined as follows by WHO (World Health Organization): “Organisms (i.e. plants, animals or microorganisms) in which the genetic mat

• br Author contribution The following are the supplementary d

  2018-11-12

  

  Author contribution The following are the supplementary data related to this article. Acknowledgments We thank Catherine Bresse for her valuable assistance in the statistical analysis. This work was supported by the CIRM grant # RL1-00636-1. Introduction The capacity of human embryonic st

• In conclusion the present study utilized an in vivo

  2018-11-12

  

  In conclusion, the present study utilized an in vivo piglet model of hypoxic-preconditioning-induced ischemic tolerance to demonstrate that PC induces proliferation and neurogenesis of endogenous NSPs up to 7days after the hypoxic–ischemic insult. PC appears as a broad, non-invasive and reproducible

• br Materials and methods br Results br

  2018-11-12

  

  Materials and methods Results Discussion We have demonstrated the efficient generation of high numbers of bfCNs from hPSCs via an expandable basal forebrain NSC intermediate. This is of particular interest as bfCNs are one of the primary populations affected in AD, and our protocol provides

• Generally histone modifications facilitate protein

  2018-11-12

  

  Generally, histone modifications facilitate protein–protein interactions with effector proteins or readers. Bromodomains interact with acetyl-lysines, while chromodomains, plant homeodomains (PHD), and others associate with methyl-lysines. Interestingly, H2AZ-containing nucleosomes associate with se

• ICG001 A key mechanism whereby macrophages may

  2018-11-12

  

  A key mechanism whereby macrophages may affect tissue repair and regeneration is by instructing the stem cell niche by paracrine mechanisms. In the mouse skeletal muscle injury model, macrophage-derived paracrine factors promote satellite cell survival, proliferation and differentiation in vitro and

• An approximate solution is sought

  2018-11-09

  

  An approximate solution is sought in the form of an output of an artificial neural network of the given architecture: whose weights are determined when minimizing the error functional and for our case, F(x, y, α) = –α(y – cosx). Test points () are chosen to be random and distributed uniformly o

• While our results provide initial evidence for the

  2018-11-09

  

  While our results provide initial evidence for the association between 5-HTTLPR genotypes and individual differences in selective attention in typically developing children, certain limitations of our study require consideration. First, the participants in this study were recruited from lower SES fa

• StemRegenin 1 As stated previously the integration of

  2018-11-09

  

  As stated previously, the integration of cognitive flexibility and emotion regulation is hypothesized to be bi-directional (Zelazo and Cunningham, 2007). Although it is clear that emotion regulation develops rapidly during the preschool years (Eisenberg, 2000), evidence of how specific emotion regul

• ML216 There are a number of reasons that make the

  2018-11-09

  

  There are a number of reasons that make the possibility to use blood-based miRNA signatures as diagnostic tools very attractive: i) cancer can be diagnosed in a minimally invasive way through a simple blood test; ii) a blood test does not require hospitalization and the access to complex and expensi

• br Immune profile of food allergy

  2018-11-09

  

  Immune profile of food allergy Despite the fact that IgE plays a central role in the pathogenesis of food allergy, measurement of food-specific IgE is not diagnostic in isolation. Quantification of food-specific IgE antibody levels in serum can identify patients in the pediatric population who ar

• br Materials and Methods br Results br Discussion

  2018-11-09

  

  Materials and Methods Results Discussion Although aberrant glycosylation is common in cancer and has been linked to PCa progression (Munkley et al., 2016), our understanding of what drives these cancer associated glycan changes has been scant and has relied upon anecdotal observations. Here

• Finally in the context of

  2018-11-09

  

  Finally, in the context of this adipose specific FABP4 transgenic (over expression) mouse model phenotype, it is essential to discuss the caveats of this animal model. In the last five years several reviews have highlighted the advantages and disadvantages of the different promoters (for example FAB

• Deregulation of miRNA expression in cancer subsequently lead

  2018-11-09

  

  Deregulation of miRNA order continine in cancer subsequently leads to altered functionality of these miRNAs. Upregulated miRNAs often act as oncogenes, as exemplified by miR-21 or miR-155 overexpression which causes acute B cell leukemia in transgenic mice models (Medina et al., 2010; Costinean et a

• br Funding br Acknowledgments br

  2018-11-09

  

  Funding Acknowledgments Introduction Adolescence is a Kinase Inhibitor Library of major change, both behaviourally and emotionally (Blakemore and Mills, 2013; Blakemore and Robbins, 2012; Crone and Dahl, 2012). Although some aspects of cognitive and behavioural performance improve during ad

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