• br Materials and method br

  2018-10-20

  

  Materials and method Results Discussion Here we took advantage of a well-characterized model of skeletal muscle damage to study the effect of FAP ablation on skeletal muscle regeneration in vivo. Our results show that Nilotinib can effectively prevent transient ECM deposition following acut

• Recently work has been focused on

  2018-10-20

  

  Recently, work has been focused on the adipose tissue-derived stromal cell (ASCs) population, since retrieval is straight forward and non-harmful coupled to low-risk surgical procedures. However, biological properties of ASCs have only been assessed by indiscriminate isolation from mostly white fat

• On the other hand cell lines VUB and

  2018-10-20

  

  On the other hand, cell lines VUB01 and VUB14 showing the highest methylation grade, expressed more HLA-G mRNA compared to the low methylated cell lines VUB19_DM1 and VUB31_FSHD suggesting that next to promoter CpG methylation other mechanisms were involved in HLA-G expression control. Cis-regulator

• brucine Determining whether the specification of most or all

  2018-10-20

  

  Determining whether the specification of most, or all, cell lineages occurs within neoblasts is essential for understanding the cellular basis for planarian regeneration. Specifically, at what cellular step in regeneration is the identity of new brucine specified? On the basis of prior results demo

• We have demonstrated that donor specific DNAm patterns are

  2018-10-20

  

  We have demonstrated that donor-specific DNAm patterns are maintained upon reprogramming into iPSCs (Shao et al., 2013), and these also remain upon redifferentiation into iPS-MSCs. Thus, there is some epigenetic memory after chromatin remodeling—whether these donor-specific DNAm patterns are functio

• An important aspect of PSC research is their

  2018-10-20

  

  An important aspect of PSC research is their theoretical ability to be differentiated into any cell type, including fgf receptor inhibitor expressing tissue-specific silencing of paternal Gsα, as described for Gsα. However, for such studies, it is critical to fully control the differentiation of th

• Functional human endothelial cells differentiated

  2018-10-20

  

  Functional human endothelial cells differentiated from hPSCs could be beneficial for many potential clinical applications (Burridge et al., 2012; Kaupisch et al., 2012; Levenberg et al., 2002; van der Meer et al., 2013), including engineering new blood vessels, endothelial cell transplantation into

• Articular cartilage is highly lubricious Lubricin encoded by

  2018-10-20

  

  Articular cartilage is highly lubricious. Lubricin encoded by the PRG4 gene and glycosaminoglycans contribute to maintaining the low friction of cartilage and directly inhibit cell adhesion (Englert et al., 2005). Therefore, since the hiPSC-derived particles expressed PRG4, it is reasonable that the

• It was previously reported that Prx Cre expresses

  2018-10-20

  

  It was previously reported that Prx1-Cre expresses in the precursors of all brown and white adipocytes in 4- to 6-week-old mice (Calo et al., 2010). This report did not indicate which depots were examined, so we could not do a perfect comparison. Nevertheless, neither our study nor Krueger et al. (2

• We have developed a protocol for the

  2018-10-20

  

  We have developed a protocol for the efficient differentiation of functional HLCs from hPSCs that does not require the addition of recombinant growth factors and is applicable to both hESCs and hiPSCs. During the development of the protocol, it came as a surprise to discover that pluripotent selecti

• Of importance was our finding of changes in other PD

  2018-10-20

  

  Of importance was our finding of changes in other PD-associated genes, including SNCA (Krüger et al., 1998; Polymeropoulos et al., 1997; Singleton et al., 2003; Zarranz et al., 2004). SNCA is a presynaptic protein and function in regulating synaptic vesicle and neurotransmitter release. Aggregates o

• One of these closely related model organisms

  2018-10-20

  

  One of these closely related model organisms is the old world monkey Macaca (mulatta or fasicularis), which follows a Carnegie staging system that is highly correlated with the timing of human development, particularly in the beginning (Fig. 1). Notably, formation of the primitive streak in macaques

• br Materials and methods br Acknowledgements This

  2018-10-20

  

  Materials and methods Acknowledgements This work was supported by grants from Instituto de Salud Carlos III (PI 15/000227 to MC, Plataforma en Red de Recursos Biomoleculares y BioinformaticosPRB2 PT13/0001/0042) cofunded by FEDER. Resource table. Resource details Loss-of-function mutation

• br Methods br Author contribution statement br Competing fin

  2018-10-20

  

  Methods Author contribution statement Competing financial interest Introduction Retinitis pigmentosa (RP) is just one of a group of heterogeneous inherited retinopathies and monogenic disorders that affect thousands of Americans and millions more worldwide (Daiger et al., 2013; Hamel, 20

• Cryopreserved peripheral blood mononuclear cells PBMC

  2018-10-20

  

  Cryopreserved peripheral blood mononuclear cells (PBMC) from this patient were used for the generation of an induced pluripotent stem cell (iPSC) that harbour a “highest risk” RET mutation according to ATA guidelines, i.e. a 2753T>C missense de novo mutation at exon 16 leading to the most frequent M

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