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br Materials and methods br Acknowledgements This
2018-10-20
Materials and methods Acknowledgements This work was supported by grants from Instituto de Salud Carlos III (PI 15/000227 to MC, Plataforma en Red de Recursos Biomoleculares y BioinformaticosPRB2 PT13/0001/0042) cofunded by FEDER. Resource table. Resource details Loss-of-function mutation
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br Methods br Author contribution statement br Competing fin
2018-10-20
Methods Author contribution statement Competing financial interest Introduction Retinitis pigmentosa (RP) is just one of a group of heterogeneous inherited retinopathies and monogenic disorders that affect thousands of Americans and millions more worldwide (Daiger et al., 2013; Hamel, 20
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Cryopreserved peripheral blood mononuclear cells PBMC
2018-10-20
Cryopreserved peripheral blood mononuclear cells (PBMC) from this patient were used for the generation of an induced pluripotent stem cell (iPSC) that harbour a “highest risk” RET mutation according to ATA guidelines, i.e. a 2753T>C missense de novo mutation at exon 16 leading to the most frequent M
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Because freshly isolated hepatocytes rapidly lose their func
2018-10-20
Because freshly isolated hepatocytes rapidly lose their functions, it is a major challenge to generate fully functional hepatocytes from pluripotent stem cells. While hepatocytes derived from CPM+ LPCs expressed high levels of metabolic activity, the levels of some proteins are not as high as primar
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A striking finding from this work is that
2018-10-20
A striking finding from this work is that, in serum-free conditions, chicken PGCs can survive and proliferate in the absence of stem cell factor (SCF). SCF (c-KIT ligand) is a requisite survival factor for mouse PGCs at early embryonic stages and for survival in short-term culture experiments (Gu et
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Gpr or T cell death associated gene
2018-10-20
Gpr65, or T cell death-associated gene 8 (Tdag8), is a proton/acid-activated GPCR (Choi et al., 1996; Wang et al., 2004). Whereas GPR65 had not been linked to HSPC transitions, it was reported to be a pro-apoptotic factor in glucocorticoid-induced lymphocyte apoptosis (Malone et al., 2004) and to re
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As a marker of cochlear supporting cells we assessed P
2018-10-20
As a marker of cochlear supporting cells, we assessed P27Kip1 localization in iCx26GJCs. P27Kip1 is a cyclin-dependent kinase inhibitor that is thought to play a role in maintaining the postmitotic state of cochlear supporting Q-VD(OMe)-OPh manufacturer such as the Deiters\' cells and outer- and inn
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Hello world!
2018-07-29
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