• Acknowledgments This work was supported by

  2018-11-14

  

  Acknowledgments This work was supported by the Agency for Science, Technology and Research, Singapore. We would like to thank the Cytogenetics laboratory at Singapore General Hospital for karyotyping the iPSC lines and Luqman Hakim for help in characterizing the iPSC lines. We would like to thank T

• Direct cell reprogramming technology is based on the dominan

  2018-11-14

  

  Direct cell-reprogramming technology is based on the dominant action of cell-lineage transcription factors (TFs) in converting adult somatic cells into different cell types (Graf and Enver, 2009). This technique represents a promising avenue in the field of regenerative medicine, with the potential

• To further investigate t http www apexbt com

  2018-11-14

  

  To further investigate the molecular program involved in HEC determination during human hematopoiesis, we generated a GATA2/eGFP reporter in H1 hESCs through gene targeting, referred as GATA2 hESCs. Based on an hPSC blood differentiation protocol in co-culturing with OP9 (Vodyanik et al., 2005), we

• The shape and the location

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  The shape and the location of this peak were examined, and the parameters necessary for constructing the Fano profile (6) were computed (see Table 2). The computed peak location is in good agreement with the experiment; unfortunately, however, since it is narrow and highly intense, no specific conc

• br Discussion There are two major

  2018-11-14

  

  Discussion There are two major explanations for these findings. First, these results are likely a reflection of the highly visible role that teeth play in North American society, and the ease with which ugly teeth and poor oral hygiene are noticed by others (Vallittu et al., 1996). This allows in

• In this study we examined the role of ADAM

  2018-11-14

  

  In this study, we examined the role of ADAM17 in colitis by developing dextran sulfate sodium (DSS)-induced colitis using two different conditional Adam17-deficient mice, i.e. mice with systemic deletion by the inducible Mx1-Cre gene of Adam17 (Adam17Mx1-Cre+) or those with its deletion in myeloid U

• Bafilomycin A1 In this issue of Vranckx and colleagues show

  2018-11-14

  

  In this issue of , Vranckx and colleagues show that a LEDGIN termed CX014442 specifically alters HIV-1 genomic integration in a manner that is similar to that associated with LEDGF depletion (). The authors carefully characterized HIV integration sites in the presence of various concentrations of CX

• We sought to further investigate the phenomenon of amoxicill

  2018-11-14

  

  We sought to further investigate the phenomenon of amoxicillin/clavulanate susceptibility using comparative genomics. A phylogenetic analysis indicated that a large proportion of MDR and XDR isolates in our dataset were part of a LAM4 clade, which was responsible for the famed Tugela Ferry XDR outbr

• Interestingly SR had an anabolic effect on

  2018-11-14

  

  Interestingly, SR10171 had an anabolic effect on the appendicular but not the axial skeleton, whereas rosiglitazone had a negative effect in both skeletal sites. There are several possible explanations for this divergence. Firstly, osteocytes were shown to be a major anabolic target of SR10171. Thes

• Fourth our findings could impact the most widely used

  2018-11-14

  

  Fourth, our findings could impact the most widely used pharmacokinetic models of maturation as commonly recommended by regulatory authorities (European Medicines Agency, 2007). Several methods are used to examine the effect of maturation on pharmacokinetic parameters, with the two most common being

• The results of multivariable regression analyses

  2018-11-14

  

  The results of multivariable regression analyses for independent predictors of xerostomia in SS participants are presented in Table 4. In a model adjusting for all potential confounders, Black/African Americans (OR: 0.40, 95% CI: 0.23–0.68, p-value=0.001) and Asians (OR: 0.49, 95% CI: 0.25–0.96, p-v

• Our mouse model is also useful for

  2018-11-14

  

  Our mouse model is also useful for studying ZIKV\'s tissue tropism and potential complications of severe ZIKV infection. In addition to the reported findings of detectable virus particles and/or RNA in the brain, spinal cord, kidney, spleen, liver, testis, ovary, heart, lung, muscle, and blood of ty

• br Methods br Results br Discussion We

  2018-11-14

  

  Methods Results Discussion We found that the odds ratio for developing IFPE as an anticoagulant gene variant carrier is the highest for SERPINC1 (144·2), followed by PROC (85·6), and PROS1 (56·4). All three SCH772984 encode established anticoagulants in balancing the effects of the procoag

• A number of limitations of

  2018-11-14

  

  A number of limitations of this study should be noted. First, owing to the extremely low incidence of nephroblastoma, the sample size of this case-control was relatively small. Consequently, statistic power of this study was compromised (statistical power no more than 0.307 for significant findings)

• Subgroup analysis by ethnicity Asian and Caucasian populatio

  2018-11-14

  

  Subgroup analysis by ethnicity (Asian and Caucasian populations) on RASSF1A promoter methylation in NPC compared with non-tumor tissues showed that methylation was associated with an increased risk of NPC in both Asian and Caucasian populations. These results suggest that RASSF1A, with promoter meth

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