• PL for actin in vitro showed that its profiles including

  2022-11-05

  

  PL for NMDA synthesis in vitro showed that its profiles, including particular peak and intensity, could determine the length and thickness of an actin filament. Furthermore, we investigated if the PL intensity peak at approximately 340 nm can also be originated from another cytoskeleton filament, s

• Apoptosis or programmed cell death is a function of

  2022-11-05

  

  Apoptosis or programmed cell death is a function of biochemical mechanisms, which are energy-dependent. It is considered to be a vital component of many processes such as normal cell cycle, immune mechanism, atrophy, embryonic development and toxin-induced cell death (Elmore, 2007). In addition, apo

• The hypothalamic pituitary adrenal HPA axis is a neuroendocr

  2022-11-05

  

  The hypothalamic-pituitary-adrenal (HPA) axis is a neuroendocrine system that is central to regulating responses to stress (Palazidou, 2012). In older persons, a high dysfunction of the HPA axis is observed (Otte et al., 2005) which may be enhanced by stimulatory effects of genes involved in the axi

• A review has recently been published to evaluate

  2022-11-05

  

  A review has recently been published to evaluate the potential effects of food, alcohol and ras pathway juices on the pharmacokinetics and pharmacodynamics of the drugs for BPH. The authors reviewed the PubMed database during the years 1991–2015. In addition, a digital version of Stockley on drug i

• Non steroidal anti inflammatory drugs which include aspirin

  2022-11-05

  

  Non-steroidal anti-inflammatory drugs, which include aspirin and ibuprofen, target COX-2 activity to inhibit inflammation. It has been shown that daily use of a nonsteroidal anti-inflammatory drugs is associated with reduced ER-positive breast cancer recurrence in obese and overweight women. More pr

• Although the earlier studies focused on the

  2022-11-05

  

  Although the earlier studies focused on the antioxidant capacity of tocopherols, ascorbic TAK-632 and carotenoids, then it was noticed that phenolic compounds were more powerful than others (Rice-Evans, Miller, & Paganga, 1996). Phenolic compounds, the most numerous and ubiquitous groups of plant s

• Ultracentrifugation of AD brain was

  2022-11-04

  

  Ultracentrifugation of AD the black and white film was reported to remove >99.95% of Aβ, while only reducing seeding capacity by 70% (Langer et al., 2011). This suggests that the most potent seeding Aβ species are relatively small soluble oligomers rather than larger insoluble fibrils. It was also

• br Discussion To our knowledge this

  2022-11-04

  

  Discussion To our knowledge, this is the first case report that demonstrates the presence of a novel T1151K ALK mutation in a patient with disease progression after crizotinib and then ceritinib. As early as 2011, Zhang et al. identified T1151K among other resistance mutations to crizotinib in Ba

• PAN induced nephrosis was accompanied by loss of body

  2022-11-04

  

  PAN-induced nephrosis was accompanied by loss of body weight, decrease of food intake, increase in urine volume and increases in triglycerides and cholesterol levels, which have been reported previously (Natori et al., 1996). Except for urine volume, each one of these measures was improved by A-3069

• sVRPs were more sensitive to ABT than

  2022-11-04

  

  sVRPs were more sensitive to ABT-702 than MSRs. This result agrees with previous reports that the activation of A1 receptors more potently inhibits sVRPs than MSRs (Nakamura et al., 1997, Otsuguro et al., 2009). Importantly, sVRPs are thought to reflex C-fiber-evoked nociceptive transmission. Nocice

• The anorexic effect observed when AR is infused into

  2022-11-04

  

  The anorexic effect observed when AR231630 is infused into the VTA could be the result of the DA release inhibition, as previously described [11]. However, there is also a hedonic aspect in feeding that possibly involves dopaminergic mechanisms of reward. Helm et al. showed a functional link between

• br Introduction The principal pathways of adrenal and

  2022-11-04

  

  Introduction The principal pathways of adrenal and gonadal steroidogenesis have been known for over 50 years (reviewed by Miller and Auchus, 2011). Cholesterol is first converted to pregnenolone via three reactions, 20-hydroxylation, 22-hydroxylation and scission of the 20,22 carbon–carbon bond,

• br Autophagy and cell death pathways in ischemic stroke Alth

  2022-11-04

  

  Autophagy and cell death pathways in ischemic stroke Although very important for the effects on post-ischemic Actinomycin D injury, autophagy is not the only mechanism of action involved in cell death. Necrosis and apoptosis are two other distinct forms of cell death with great difference in morp

• Previous studies have demonstrated ATR inhibition is effecti

  2022-11-04

  

  Previous studies have demonstrated ATR inhibition is effective for treating cancers combining with chemotherapies in lung adenocarcinoma, gastric cancer, HER2 positive breast cancer and chronic lymphocytic leukemia scr 11 to enhance chemotherapy sensitivity [[16], [17], [18],[20], [21], [22]]. VE-8

• Despite their different effects on cell survival

  2022-11-04

  

  Despite their different effects on cell survival, the functions of autophagy and apoptosis are not completely independent. Additionally, Cho et al. (2009) suggested that the mediation of caspase-3 links the apoptotic and autophagic signaling pathways. Consequently, to illuminate the correlation, exc

16048 records 376/1070 page Previous Next First page 上5页 376377378379380 下5页 Last page