• The following are the supplementary data related

  2021-12-23

  

  The following are the supplementary data related to this article. Transparency Document Acknowledgements Introduction Nitric oxide (NO) is an important signaling molecule mediating several physiological functions including vasodilation, platelet anti-aggregation, inhibition of interstitial

• br Introduction The Ras superfamily of small GTPases is

  2021-12-23

  

  Introduction The Ras superfamily of small GTPases is composed of more than 150 protein members involved in a wide variety of biological processes, such as proliferation, differentiation, cytoskeletal organization, and protein trafficking [1]. The Ras superfamily proteins act as molecular switches

• In the liver ghrelin has opposite effects to insulin on

  2021-12-23

  

  In the liver, ghrelin has opposite effects to insulin on the expression of the enzyme PEPCK, thereby promoting gluconeogenesis and also causing a decrease in glucose uptake and fatty HOBt synthesis oxidation (Rigault et al., 2007). Ghrelin also stimulates hepatic lipogenesis de novo in a GH-indepen

• br Materials and methods br Results br

  2021-12-23

  

  Materials and methods Results Discussion Although homologues of the β-galactosidase gene were known to exist in the Xenopus genome, and SA-β-gal activity has been detected in whole-mount Xenopus embryos by histochemical staining (Davaapil et al., 2017), no reports have been presented so far

• Stimulation of FPR by bacterial

  2021-12-22

  

  Stimulation of FPR by bacterial N-formyl peptides induces basophil and mast nebivolol hcl mg release of immunogenic compounds such as histamine [21], [31]. Furthermore, we demonstrated that histamine plays a role in F-MITs-induced sepsis-like symptoms since cimetidine, a histamine H2-receptor antag

• br Acknowledgments This study was supported by a Conquer

  2021-12-22

  

  Acknowledgments This study was supported by a Conquer Cancer Foundation (American Society for Clinical Oncology) Drug Development Research Professorship Grant (AAA). Introduction Gastric cancer (GC) is one of difficult cancers to treat in terms of its poor prognosis and limited applicability

• PKC potentiates insulin release in beta cells however it is

  2021-12-22

  

  PKC potentiates insulin release in beta cells; however, it is currently not clear how this is mechanistically accomplished in living ESI-09 [15]. First, we discuss PKC structure, regulation, and activation in beta cells. Then, we address two fundamental questions: (1) what is the specific effect of

• On the other hand imidazolylcyclopropane derivatives and hav

  2021-12-22

  

  On the other hand, imidazolylcyclopropane derivatives and having a 2-substituted benzimidazolyl group showed moderate binding affinities for both the HR and HR. Replacement of 4-chlororbenzylamino group of with a benzimidazolyl group () led to increase the affinity for the HR more than 5-fold ( =

• br Results and discussion br Conclusions

  2021-12-22

  

  Results and discussion Conclusions In summary, we generated analogues of the hit compounds 1–3, studied their structure–activity relationships, and created a series of highly potent GPR55 agonists. The most potent agonists among the series were 17a-b, 17e, 17g and 17l with EC50 values below 10

• En el caso de la foliculitis decalvante FD se ha

  2021-12-22

  

  En el caso de la foliculitis decalvante (FD), se ha publicado un estudio multicéntrico español de 82 pacientes en el que se concluye que el tratamiento que consigue una mayor efectividad (mejora en 15/15 pacientes tratados) y un mayor periodo de remisión postratamiento (7,2 meses) es la combinación

• Based on these findings we set out to identify

  2021-12-22

  

  Based on these findings, we set out to identify GPR109A agonists capable of biasing the receptor's signaling towards the functional anti-lipolytic and presumed therapeutic response, and away from the flushing side-effect pathways. Indeed, using recombinantly expressed GPR109A, two classes of compoun

• In recent large clinical studies AIM HIGH and HPS

  2021-12-22

  

  In recent large clinical studies, AIM-HIGH and HPS2-THRIVE, the additional treatment of nicotinic molar volume calculator to statin-based LDL-C lowering therapy did not decrease the major vascular events on the patients who had atherosclerotic vascular diseases [43,44]. In the AIM-HIGH study, the s

• Many studies support that Gli

  2021-12-22

  

  Many studies support that Gli transcription factors are not solely regulated by Hh/smo signaling but are also influenced by crosstalk with other pathways, such as RAS, PI3K/AKT, transforming growth factor-b/SMAD, PKC, or extracellular signal-regulated kinase pathways which are downstream and indepen

• br Some Gardos channel perplexities While much

  2021-12-22

  

  Some Gardos channel perplexities While much is known about the Gardos channel (inside Ca2+-activated K+ channel) and it's characteristics in human red blood 71 8 (e.g. [18,19]), there are a number of intriguing and unexplained phenomena that are in much need of study. One is that activation of t

• br Signals transmitted via MEGJ MEGJ facilitate the

  2021-12-22

  

  Signals transmitted via MEGJ MEGJ facilitate the direct transfer of ion currents or small molecules between EC and VSMC. Molecules passing through MEGJ are mainly second messengers such as Ca2+, IP3, and cAMP [31,32,] or endothelium-derived hyperpolarization (EDH) signals [34, 35, 36]. Moreover,

15728 records 507/1049 page Previous Next First page 上5页 506507508509510 下5页 Last page