• The liposomes as a FDA

  2020-10-26

  

  The liposomes, as a FDA-approved drug delivery carrier, have been widely utilized for drug delivery [32], [33], [34]. Liposomes are defined as self-assembled vesicles, which are composed of one or multiple concentric lipid bilayers and enclose an aqueous core. The advantages of utilizing liposomes a

• Related with the studies by

  2020-10-26

  

  Related with the studies by Zizza et al. described above [66], work by Ward et al. [68] suggested that the C2 domain of cPLA2α, which binds to zwitterionic membranes with high affinity in a Ca2+-dependent manner, has a high membrane remodeling activity, producing dramatic changes in membrane curvatu

• Cyclin D inhibits the transcriptional activity

  2020-10-26

  

  Cyclin D1 inhibits the transcriptional activity of the transcription factors myogenin and MEF2 [39,40]. In addition, myogenin activates MEF2 expression, which feeds back to amplify the myogenin promoter [38]. In this study, DGKδ suppression, in addition to the increase of cyclin D1, inhibited myogen

• DGK is also involved in

  2020-10-26

  

  DGKδ is also involved in cell differentiation. Previously, to investigate the physiological roles of DGKδ, DGKδ-deficient mice have been generated. On the basis of the analysis of DGKδ-deficient mice, Crotty et al. reported that DGKδ regulates the epidermal growth factor receptor (EGFR) pathway by a

• br Sphingosine kinase One of

  2020-10-26

  

  Sphingosine kinase One of the enzymes closely related to DGKs are the sphingosine kinases (SKs). These enzymes catalyze the conversion of sphingosine (Sph) to sphingosine-1-phosphate (S1P). SKs and DGKs are closely related lipid kinase in term of basic enzymology and the mechanism of regulation a

• Despite low respiratory rates in citrus

  2020-10-26

  

  Despite low respiratory rates in citrus fruit, prolonged periods of storage may cause significant changes in the levels of organic acids (Echeverria and Valich, 1988). V-ATPase and V-PPase catalyze the electrogenic H+ translocation from the cytosol to the vacuolar lumen to generate an inside-acid pH

• Each nsP plays a distinct defined and

  2020-10-26

  

  Each nsP plays a distinct, defined and indispensable role in the replication of viral genome. nsP1 is a membrane associated protein which possesses S-adenosyl-L-methionine (SAM)-dependent methyltransferase (MTase) and guanylyltransferase (GTase) activities to catalyze the viral RNA capping reaction

• The physiological role of the UCNs in the regulation of

  2020-10-26

  

  The physiological role of the UCNs in the regulation of the HPA axis is still under debate (Fekete and Zorrilla, 2007, Suda et al., 2004). UCN 1 was proved to increase the plasma ACTH and corticosterone levels in rats (Bagosi et al., 2014, Vaughan et al., 1995), whereas UCN 2 and UCN 3 were shown to

• br Materials and methods br Results br Discussion In

  2020-10-26

  

  Materials and methods Results Discussion In this study, the N&B analysis showed new evidence regarding the proportion and the oligomerization state of the AT1 and the ETA receptors near or on the plasma membrane. Althought, preliminary studies suggest that the AT1 and the ETA receptors occu

• Functional studies revealed that these ESR mutations lead

  2020-10-26

  

  Functional studies revealed that these ESR1 mutations lead to constitutive activity of the ER, meaning that the receptor is active in absence of estrogen, conferring resistance against several endocrine agents. Recent studies reported that the occurrence of ESR1 mutations is rare in ER+ primary brea

• Our previous studies indicate that EBI is

  2020-10-23

  

  Our previous studies indicate that EBI2 is involved in the regulation of pro-inflammatory responses and inter-cellular communication under pathophysiological conditions such as LPS challenge (Rutkowska et al., 2016b). The data showed that media taken from LPS stimulated astrocytes induces macrophage

• br Conflict of interest br Acknowledgements

  2020-10-23

  

  Conflict of interest Acknowledgements The authors are grateful to laboratory technician Kristina Andersson for expert technical assistance. The authors acknowledge the Swedish Research Council (Grant no. 6834), Region Skåne and Faculty of Medicine, Lund University, for financial support. In

• br Synthesis and mechanism of fluorescent DNA CuNMs

  2020-10-23

  

  Synthesis and mechanism of fluorescent DNA-CuNMs Application of fluorescent DNA-CuNMs Summary and conclusions In summary, we introduce recent research progress in the synthesis and various applications of DNA-CuNMs. DNA-CuNMs with novel catalytic, electrical and optical properties can be ob

• br Other Alterations in Triglyceride Metabolism in DGAT Defi

  2020-10-23

  

  Other Alterations in Triglyceride Metabolism in DGAT-Deficient Mice Consistent with the enzyme\'s ubiquitous expression pattern, DGAT deficiency also altered triglyceride metabolism in other tissues. For example, postpartum Dgat−/− female mice were unable to nurse their young owing to an absence

• br Introduction Lycium barbarum also known

  2020-10-23

  

  Introduction Lycium barbarum, also known as wolfberry, belongs to the plant family Solanaceae. Red-coloured fruits of L. barbarum are used as traditional Chinese herbal medicine to promote health and longevity and as a food supplement for thousands of years [1]. They possess many biological activ

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