• To further validate OsSCE gene function in relation to

  2020-07-31

  

  To further validate OsSCE1 gene function in relation to drought stress, we established OsSCE1-OX (overexpressed) and OsSCE1-KD (knockdown) transgenic rice plants. Drought stress analysis using PEG6000 showed the selected OsSCE1-OX line (S15.1) had a lower tolerance to drought stress than WT plants (

• Structural data are most complete for Uba E yeast and

  2020-07-31

  

  Structural data are most complete for Uba1 (E1) yeast, and the human and yeast profiles are compared in Fig. 3. The differences are small, and are mentioned in the Fig. 3 caption. Before we compare the long-range (“allosteric”) correlations of these figures, we show in Fig. 4 the results for fruit f

• br Transparency document br Main Text The centrosome

  2020-07-31

  

  Transparency document Main Text The centrosome is a non-membrane-bound organelle found in most animal cells. It has several important functions, including control of cilia formation, microtubule organization and nucleation, spindle assembly and transport of organelles and vesicles. Centrosomes

• Proof of concept studies with disulfiram suggest

  2020-07-31

  

  Proof-of-concept studies with disulfiram suggest the potential utility of DβH inhibitors for treatment of cocaine use disorder. In a study of 74 subjects stabilized on methadone and randomized into disulfiram and placebo groups for 10weeks, disulfiram treatment reduced cocaine-positive urines, and d

• In the present study DRD decreased in the

  2020-07-31

  

  In the present study, DRD3 decreased in the VTA of OA when compared with the control group. It is reported that DRD3 in the VTA control the firing rate of dopaminergic neurons and inhibition of these receptors enhance firing in the VTA-projecting neurons [18]. A study also indicated that morphine tr

• br Materials and methods The three pieces

  2020-07-31

  

  Materials and methods The three pieces of cotton fabric were submitted to the analysis: evidence no. 1 was a white handkerchief with visible yellow stiff stains and lacerations perhaps related to multiple cuts for old sampling; evidence no. 2 was a piece of white and green cotton fabric showing b

• Our results on the acute effects of

  2020-07-31

  

  Our results on the acute effects of THC on resting state L-Arabinose function are in line with previous neuroimaging findings. Increased perfusion after THC administration in insular and prefrontal regions has previously been reported in smaller samples (Mathew et al., 1997, Mathew et al., 2002, va

• Sensory gating describes a filter

  2020-07-31

  

  ‘Sensory gating’ describes a filter mechanism protecting the central nervous system from sensory overload by inhibiting behaviorally irrelevant input (Boutros et al., 2004, 2008). This permits Pyrene azide 3 to a changing contextual environment (Fruhstorfer et al., 1970; Grunwald et al., 2003). Aud

• br Acknowledgments br Protein kinase CK represents a unique

  2020-07-31

  

  Acknowledgments Protein kinase CK1 represents a unique and well-conserved group of protein kinases within the superfamily of serine/threonine kinases that is ubiquitously expressed in eukaryotic organisms. Recently, seven mammalian CK1 isoforms have been identified (α, β, γ1, γ2, γ3, δ, ε) with

• br Relevance of DHODH in

  2020-07-30

  

  Relevance of DHODH in cancer DHODH\'s relevance in cancer was recognized nearly six decades ago when Smith et al. noted elevated DHODH activity in leukemic WYE-125132 (Smith, Baker, & Sullivan, 1960; Smith Jr. & Baker, 1959). Following that observation, several investigations focused on DHODH th

• In normolipidemic CD and C BL mice the maximal

  2020-07-30

  

  In normolipidemic CD-1 and C57BL/6 mice, the maximal increase in serum triglycerides was observed two h after corn oil administration with triglycerides returning towards baseline levels within three h. However, in dyslipidemic ob/ob and apoE−/− mice, serum triglycerides were incrementally increased

• Furthermore our sample preparation uses a simple isolation

  2020-07-30

  

  Furthermore, our sample preparation uses a simple isolation procedure. Numerous CYP450 phenotyping methods employed extensive extraction procedures for sample preparation such as dual liquid extraction or solid phase extraction which are costly and time consuming [10], [17], [18], [19], [20], [23],

• As described above we designed a novel isoquinoline

  2020-07-30

  

  As described above, we designed a novel isoquinoline scaffold and synthesized TSU-68 15-1, based on the superimposition of the critical P1, P2, and P3 sites of known CRTH2 antagonists (Fig. 2). Inspection of the key interaction between the binding pocket of CRTH2 and the P1 and P2 sites of the CRTH2

• MTX is a major component of the curative treatment

  2020-07-30

  

  MTX is a major component of the curative treatment of childhood ALL, and the extent of accumulation of its active polyglutamates (MTXPG) determines its cytotoxicity and influences treatment response in childhood ALL. GGH converts long-chain MTXPG into shorter-chain MTXPG and ultimately into MTX, whi

• The enzyme can also be used

  2020-07-30

  

  The enzyme can also be used in a targeted cancer therapy technique known as Antibody Directed Enzyme Prodrug Therapy (ADEPT), which has already been implemented for cancer treatment.(Bagshawe et al., 1988) ADEPT consists of two steps (Fig. 1), which result in the production of a powerful cytotoxic

16047 records 803/1070 page Previous Next First page 上5页 801802803804805 下5页 Last page