• Dexamethasone DEX a potent synthetic glucocorticoid

  2019-11-11

  

  Dexamethasone (DEX), a potent synthetic glucocorticoid drug, is effective for treatment of a range of inflammatory and autoimmune conditions as well as the reduction of side effects associated with chemotherapy. On the Czech Republic pharmaceutical market, DEX is incorporated into eighteen drugs use

• As plants can only take up P in an inorganic

  2019-11-11

  

  As plants can only take up P in an inorganic orthophosphate form, it was expected that the proportion of orthophosphate P in the OA would be a good indication of the availability of the P in the OA. While the P speciation of the COMP sample could not be determined by deconvolution due to the broadne

• Ultrasound is an acoustic wave

  2019-11-11

  

  Ultrasound is an acoustic wave with a frequency >20 kHz that needs a medium to propagate [20]. Accompanied by the spread of an ultrasonic wave, a series of alternating cycles of compression and rarefaction emerge in the liquid medium. During the rarefaction cycle, microbubbles are formed because of

• br Introduction As a serine proteinase

  2019-11-11

  

  Introduction As a serine proteinase and a sub-family of the chymotrypsin-like proteinase, Glutamyl endopeptidase (GE), which is mainly found in Bacillus species, specifically cleaves negatively charged amino 2365 residues (Glu/Asp) (Yokoi et al., 2001). Madsen et al. (Madsen & Qvist, 1997) repor

• In attempts to further purify His Artemis numerous

  2019-11-11

  

  In attempts to further purify [His]6-Artemis, numerous matrices were assessed including anion and cation exchange, and LGX818 interaction chromatography. The results from these matrices were universally poor (data not shown). Fractionation via adsorption chromatography on a hydroxyapatite (HAP) mat

• The number of DBH alleles affects dopamine and norepinephrin

  2019-11-08

  

  The number of DBH SIS3 affects dopamine and norepinephrine levels in the prefrontal cortex of mice when they are treated with disulfiram (33). Disulfiram increased dopamine and decreased norepinephrine levels in their prefrontal cortex of mice with two normal alleles, whereas disulfiram showed rela

• DNA methylation is associated with transcriptional silencing

  2019-11-08

  

  DNA methylation is associated with transcriptional silencing of tumor suppressors or other genes important for normal cellular function and plays an important role in the development of cancer and other diseases (such as breast and colorectal cancers) [19]. DNA methyltransferases (MTases) are a fami

• br Introduction Coping with DNA damage is possible thanks to

  2019-11-08

  

  Introduction Coping with DNA damage is possible thanks to surveillance mechanisms (checkpoints), that detect the problem and promote its solution [1], [2], and to repair and tolerance pathways that remove the lesions or reduce the damage consequences [3], [4]. Failures in these processes have a h

• DGK negatively regulated the extension of long axon neurite

  2019-11-08

  

  DGKδ negatively regulated the extension of long axon/neurite (Fig. 4, Fig. 5, Fig. 6). The results strongly suggest that deficiency of DGKδ induces OCD-like behavior by enhancing axon/neurite outgrowth. DGKδ positively regulates growth factor signaling (Crotty et al., 2006). Therefore, DGKδ deficien

• Compound was advanced to a chronic efficacy study in db

  2019-11-08

  

  Compound 52 was advanced to a chronic efficacy study in db/db mice maintained on a high fat diet. Animals were dosed with 0.5% methylcellulose vehicle, Safingol 52 (1, 3 or 15mg/kg, po, Q.D.) or 1 (0.3mg/kg) for 14days. Over the course of the study body weight and food intake were measured daily fo

• br Authors contributions br Acknowledgements br Introduction

  2019-11-08

  

  Authors’ contributions Acknowledgements Introduction Retinoic (S)-Mephenytoin mg is a key signalling molecule in healthy development and in differentiation of stem cells, albeit uncontrolled levels of retinoic acid can lead to mutagenesis [1]. In eukaryotes retinoic acid is made by oxidatio

• Xenobiotic metabolism primarily occurs in liver which contai

  2019-11-08

  

  Xenobiotic metabolism primarily occurs in liver, which contains many enzymes to catalyze the transformation of xenobiotic. Usually, cytochrome P-450s (CYP450s) act as the first response for biotransformation of xenobiotic in organisms. CYP450s generally consist of various subfamily enzymes which can

• The pyrrolo benzodiazepines PBDs are a

  2019-11-08

  

  The pyrrolo[2,1-][1,4]benzodiazepines (PBDs) are a family of antitumour antibiotics that includes the natural products anthramycin and DC-81. They exert their cytotoxicity by covalently bonding to the exocyclic C2–NH group of guanine residues in the minor groove of DNA through their N10–C11 imine fu

• Concerning firmness postharvest calcium dips for whole fruit

  2019-11-08

  

  Concerning firmness, postharvest calcium dips for whole fruit have been demonstrated to preserve firmness, cell wall structure (Glenn and Poovaiah, 1990), nutritional quality (Goldberg, 1984) and fruit flavour (Ortiz et al., 2009). Similarly, combinations of calcium treatment (0.5–4%) with packaging

• Accurate equilibrium predictions of CO containing mixtures h

  2019-11-08

  

  Accurate equilibrium predictions of CO2 containing mixtures, however, are challenging with traditional equations of state. The reason for this may be that CO2 has a large quadrupole moment. The large quadrupole moment of CO2, as well as size asymmetry, are for instance believed to be the reasons for

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